HI there - hope you're well!
Our first question when this is requested of us is 'why are you looking to disable the automatically inserted ads'.
If you're able to provide us with a description of what's occurring on the site that's prompting this request, it allows us to offer you the best possible advice / help to make a decision around the setup.
Sometimes, disabling the auto-ads is what's right for a situation - but more often than not another solution is found that doesn't negatively affect the potential earnings as much as a complete disabling of the feature would cause.
We also like to make sure you're aware of the effort that would need to be put in to setup fully manually, and what sort of revenue potential ramifications occur as a result.